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The GTPase-deficient Rab27A(Q78L) Mutant Inhibits Melanosome Transport in Melanocytes through Trapping of Rab27A Effector Protein Slac2-a/Melanophilin in Their Cytosol: DEVELOPMENT OF A NOVEL MELANOSOME-TARGETING TAG

The small GTPase Rab27A is a crucial regulator of actin-based melanosome transport in melanocytes, and functionally defective Rab27A causes human Griscelli syndrome type 2, which is characterized by silvery hair. A GTPase-deficient, constitutively active Rab27A(Q78L) mutant has been shown to act as...

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Detalhes bibliográficos
Main Authors: Ishida, Morié, Arai, Saki P., Ohbayashi, Norihiko, Fukuda, Mitsunori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036246/
https://ncbi.nlm.nih.gov/pubmed/24584932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.552281
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