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Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemia.

The characterization of 4a-carbinolamine dehydratase with the enzymatically synthesized natural substrate revealed non-Michaelis-Menten kinetics. A Hill coefficient of 1.8 indicates that the dehydratase exists as a multisubunit enzyme that shows cooperativity. A mild form of hyperphenylalaninemia wi...

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Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Johnen, G, Kowlessur, D, Citron, B A, Kaufman, S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 1995
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40362/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8618906/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.26.12384
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