PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

Drug discovery in psychiatry has been limited to chemical modifications of compounds originally discovered serendipitously. Therefore, more mechanism-oriented strategies of drug discovery for mental disorders are awaited. Schizophrenia is a devastating mental disorder with synaptic disconnectivity i...

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Main Authors: Hayashi-Takagi, Akiko, Araki, Yoichi, Nakamura, Mayumi, Vollrath, Benedikt, Duron, Sergio G., Yan, Zhen, Kasai, Haruo, Huganir, Richard L., Campbell, David A., Sawa, Akira
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035976/
https://ncbi.nlm.nih.gov/pubmed/24706880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321109111
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