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Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins

The protein quality control (QC) system protects cells against cellular toxicity induced by misfolded proteins and maintains overall cellular fitness. Inefficient clearance of or failure to degrade damaged proteins causes several diseases, especially age-linked neurodegenerative disorders. Attenuati...

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Bibliografiske detaljer
Main Authors: Chhangani, Deepak, Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Mishra, Amit
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035578/
https://ncbi.nlm.nih.gov/pubmed/24865853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05077
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