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Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine
OBJECTIVE: Enterochromaffin cell-derived serotonin (5-HT) promotes intestinal inflammation. We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal in...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4034681/ https://ncbi.nlm.nih.gov/pubmed/23749550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2013-304901 |
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