The Hypoxia-Inducible Factor Pathway, Prolyl Hydroxylase Domain Protein Inhibitors, and Their Roles in Bone Repair and Regeneration

Hypoxia-inducible factors (HIFs) are oxygen-dependent transcriptional activators that play crucial roles in angiogenesis, erythropoiesis, energy metabolism, and cell fate decisions. The group of enzymes that can catalyse the hydroxylation reaction of HIF-1 is prolyl hydroxylase domain proteins (PHDs...

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Bibliographic Details
Main Authors: Fan, Lihong, Li, Jia, Yu, Zefeng, Dang, Xiaoqian, Wang, Kunzheng
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2014
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034436/
https://ncbi.nlm.nih.gov/pubmed/24895555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/239356
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