Hypochlorite-induced structural modifications enhance the chaperone activity of human α(2)-macroglobulin

Hypochlorite, an oxidant generated in vivo by the innate immune system, kills invading pathogens largely by inducing the misfolding of microbial proteins. Concomitantly, the nonspecific activity of hypochlorite also damages host proteins, and the accumulation of damaged (misfolded) proteins is impli...

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Detaylı Bibliyografya
Asıl Yazarlar: Wyatt, Amy R., Kumita, Janet R., Mifsud, Richard W., Gooden, Cherrie A., Wilson, Mark R., Dobson, Christopher M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034205/
https://ncbi.nlm.nih.gov/pubmed/24799681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403379111
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