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Hypochlorite-induced structural modifications enhance the chaperone activity of human α(2)-macroglobulin

Hypochlorite, an oxidant generated in vivo by the innate immune system, kills invading pathogens largely by inducing the misfolding of microbial proteins. Concomitantly, the nonspecific activity of hypochlorite also damages host proteins, and the accumulation of damaged (misfolded) proteins is impli...

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Autori principali: Wyatt, Amy R., Kumita, Janet R., Mifsud, Richard W., Gooden, Cherrie A., Wilson, Mark R., Dobson, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034205/
https://ncbi.nlm.nih.gov/pubmed/24799681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403379111
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