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Hypochlorite-induced structural modifications enhance the chaperone activity of human α(2)-macroglobulin
Hypochlorite, an oxidant generated in vivo by the innate immune system, kills invading pathogens largely by inducing the misfolding of microbial proteins. Concomitantly, the nonspecific activity of hypochlorite also damages host proteins, and the accumulation of damaged (misfolded) proteins is impli...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4034205/ https://ncbi.nlm.nih.gov/pubmed/24799681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403379111 |
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