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Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K(+) channel function

Studies of stress effects on the brain have traditionally focused on neurons, without considering the cerebral microcirculation. Here we report that stress impairs neurovascular coupling (NVC), the process that matches neuronal activity with increased local blood flow. A stressed phenotype was induc...

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Detalhes bibliográficos
Main Authors: Longden, Thomas A., Dabertrand, Fabrice, Hill-Eubanks, David C., Hammack, Sayamwong E., Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034203/
https://ncbi.nlm.nih.gov/pubmed/24808139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401811111
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