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Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity
T-cell activation, proliferation and selection of the cell death pathway depend on the production of reactive oxygen intermediates (ROIs) and ATP synthesis, which are tightly regulated by the mitochondrial transmembrane potential (ΔΨ(m)). Mitochondrial hyperpolarization (MHP) and ATP depletion repre...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4034110/ https://ncbi.nlm.nih.gov/pubmed/15207503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2004.05.001 |
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