A PHOSPHOPEPTIDE MIMETIC PRODRUG TARGETING THE SH2 DOMAIN OF STAT3 INHIBITS TUMOR GROWTH AND ANGIOGENESIS

Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a number of human cancers and cancer cell lines. Via its Src homology 2 (SH2) domain, Stat3 is recruited to phosphotyrosine residues on intracellular domains of cytokine and growth factor receptors, whereupon i...

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Detalhes bibliográficos
Main Authors: Auzenne, Edmond J., Klostergaard, Jim, Mandal, Pijus K., Liao, Warren S., Lu, Zhen, Gao, Fengqin, Bast, Robert C., Robertson, Fredika M., McMurray, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033579/
https://ncbi.nlm.nih.gov/pubmed/23350355
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