Pharmacological inhibition of a microRNA family in non-human primates by a seed-targeting 8-mer antimiR

MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base-pairing with 3’ UTRs, primarily via seed sequences (nucleotides 2-8 in the mature miRNA sequence). A number of individual miRNAs and miRNA families share seed sequenc...

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Main Authors: Rottiers, Veerle, Obad, Susanna, Petri, Andreas, McGarrah, Robert, Lindholm, Marie W., Black, Joshua C., Sinha, Sumita, Goody, Robin J., Lawrence, Matthew S., deLemos, Andrew S., Hansen, Henrik F., Whittaker, Steve, Henry, Steve, Brookes, Rohn, Najafi-Shoushtari, S. Hani, Chung, Raymond T., Whetstine, Johnathan R., Gerszten, Robert E., Kauppinen, Sakari, Näär, Anders M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033576/
https://ncbi.nlm.nih.gov/pubmed/24259050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006840
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