A Computer Simulation Approach to Assessing Therapeutic Intervention Points for the Prevention of Cytokine-Induced Cartilage Breakdown

OBJECTIVE: To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test possible interventions for reducing collagen release. METHODS: We constructed a computational model of the relevant molecular pathways using the S...

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Hlavní autoři: Proctor, CJ, Macdonald, C, Milner, JM, Rowan, AD, Cawston, TE
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Chondrocyte Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033570/
https://ncbi.nlm.nih.gov/pubmed/24757149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38297
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