Early hypersynchrony in juvenile PINK1(−)/(−) motor cortex is rescued by antidromic stimulation

In Parkinson’s disease (PD), cortical networks show enhanced synchronized activity but whether this precedes motor signs is unknown. We investigated this question in PINK1(−)/(−) mice, a genetic rodent model of the PARK6 variant of familial PD which shows impaired spontaneous locomotion at 16 months...

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Detalhes bibliográficos
Main Authors: Carron, Romain, Filipchuk, Anton, Nardou, Romain, Singh, Abhinav, Michel, Francois J., Humphries, Mark D., Hammond, Constance
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033197/
https://ncbi.nlm.nih.gov/pubmed/24904316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsys.2014.00095
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