A Neurobiological Hypothesis of Treatment-Resistant Depression – Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy

First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates following two trials of an SSRI are <50%. The authors examine the putative biological substrates underlying “treatment resistant depression...

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Detalhes bibliográficos
Main Authors: Coplan, Jeremy D., Gopinath, Srinath, Abdallah, Chadi G., Berry, Benjamin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033019/
https://ncbi.nlm.nih.gov/pubmed/24904340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00189
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