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Methods of solving rapid binding target-mediated drug disposition model for two drugs competing for the same receptor
The target-mediated drug disposition (TMDD) model has been adopted to describe pharmacokinetics for two drugs competing for the same receptor. A rapid binding assumption introduces total receptor and total drug concentrations while free drug concentrations C(A) and C(B) are calculated from the equil...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032368/ https://ncbi.nlm.nih.gov/pubmed/22926955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-012-9267-z |
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