Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats

BACKGROUND: Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced a...

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Detalhes bibliográficos
Main Authors: Ge, Yanhu, Wu, Feixiang, Sun, Xuejun, Xiang, Zhenghua, Yang, Liqun, Huang, Shengdong, Lu, Zhijie, Sun, Yuming, Yu, Wei-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032255/
https://ncbi.nlm.nih.gov/pubmed/24857932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097436
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