Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo

We developed a common feature pharmacophore model using known antiadipogenic compounds (CFPMA). We identified rohitukine, a reported chromone anticancer alkaloid as a potential hit through in silico mapping of the in-house natural product library on CFPMA. Studies were designed to assess the antiadi...

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Autors principals: Varshney, Salil, Shankar, Kripa, Beg, Muheeb, Balaramnavar, Vishal M., Mishra, Sunil Kumar, Jagdale, Pankaj, Srivastava, Shishir, Chhonker, Yashpal S., Lakshmi, Vijai, Chaudhari, Bhushan P., Bhatta, Rabi Shankar, Saxena, Anil Kumar, Gaikwad, Anil Nilkanth
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031934/
https://ncbi.nlm.nih.gov/pubmed/24646949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M039925
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