Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine

The interaction of chemokines with glycosaminoglycans (GAGs) facilitates the formation of localized chemokine gradients that provide directional signals for migrating cells. In this study, we set out to understand the structural basis and impact of the differing oligomerization propensities of the c...

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Bibliographic Details
Main Authors: Salanga, Catherina L., Dyer, Douglas P., Kiselar, Janna G., Gupta, Sayan, Chance, Mark R., Handel, Tracy M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031540/
https://ncbi.nlm.nih.gov/pubmed/24727473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547737
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