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Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling

BACKGROUND: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes' interactions on which a pathway's cellular function depends. In contrast, PathWave has been developed for the analysis of high-t...

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Detalhes bibliográficos
Main Authors: Piro, Rosario M, Wiesberg, Stefan, Schramm, Gunnar, Rebel, Nico, Oswald, Marcus, Eils, Roland, Reinelt, Gerhard, König, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031158/
https://ncbi.nlm.nih.gov/pubmed/24886210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-8-56
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