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Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucia...

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Main Authors: Schauer, Grant, Leuba, Sanford, Sluis-Cremer, Nicolas
格式: Artigo
語言:Inglês
出版: MDPI 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030976/
https://ncbi.nlm.nih.gov/pubmed/24970195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom3040889
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