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Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues
[Image: see text] 5,6-Dihydroxyindole-2-carboxylic acid (DHICA), an intermediate of melanin synthesis and an eumelanin building block, was recently discovered to be a GPR35 agonist with moderate potency. Here, we report the synthesis and pharmacological characterization of a series of DHICA analogue...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030800/ https://ncbi.nlm.nih.gov/pubmed/24900508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300076u |
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