Targeted Ablation of Connexin26 in the Inner Ear Epithelial Gap Junction Network Causes Hearing Impairment and Cell Death

Mutations in the gene encoding the gap junction protein connexin26 (Cx26) are responsible for the autosomal recessive isolated deafness, DFNB1, which accounts for half of the cases of prelingual profound hereditary deafness in Caucasian populations [1–5]. To date, in vivo approaches to decipher the...

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Main Authors: Cohen-Salmon, Martine, Ott, Thomas, Michel, Vincent, Hardelin, Jean-Pierre, Perfettini, Isabelle, Eybalin, Michel, Wu, Tao, Marcus, Daniel C., Wangemann, Philine, Willecke, Klaus, Petit, Christine
Format: Artigo
Sprog:Inglês
Udgivet: 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030438/
https://ncbi.nlm.nih.gov/pubmed/12121617
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