Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

Pemetrexed is approved for first-line and maintenance treatment of patients with advanced or metastatic non-small-cell lung cancer (NSCLC). The protein kinase Akt/protein kinase B is a well-known regulator of cell survival which is activated by pemetrexed, but its role in pemetrexed-mediated cell de...

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Détails bibliographiques
Auteurs principaux: Chen, Kun-Chieh, Yang, Tsung-Ying, Wu, Chun-Chi, Cheng, Chi-Chih, Hsu, Shih-Lan, Hung, Hsiao-Wen, Chen, Jian-Wei, Chang, Gee-Chen
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029963/
https://ncbi.nlm.nih.gov/pubmed/24847863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097888
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