Peptide Carrier-Mediated Non-Covalent Delivery of Unmodified Cisplatin, Methotrexate and Other Agents via Intravenous Route to the Brain

BACKGROUND: Rapid pre-clinical evaluation of chemotherapeutic agents against brain cancers and other neurological disorders remains largely unattained due to the presence of the blood-brain barrier (BBB), which limits transport of most therapeutic compounds to the brain. A synthetic peptide carrier,...

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Hlavní autoři: Sarkar, Gobinda, Curran, Geoffry L., Sarkaria, Jann N., Lowe, Val J., Jenkins, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029735/
https://ncbi.nlm.nih.gov/pubmed/24847943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097655
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