Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion

Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs (miRNA) whose targets are just being uncovered. Moreover, miRNA function during the virus life cycle is relatively unknown. We find that HCMV miRs UL112-1, US5-1, and US5-2 target multiple components of the host secreto...

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Main Authors: Hook, Lauren M, Grey, Finn, Grabski, Robert, Tirabassi, Rebecca, Doyle, Tracy, Hancock, Meaghan, Landais, Igor, Jeng, Sophia, McWeeney, Shannon, Britt, William, Nelson, Jay A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029511/
https://ncbi.nlm.nih.gov/pubmed/24629342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.02.004
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