Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion

Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs (miRNA) whose targets are just being uncovered. Moreover, miRNA function during the virus life cycle is relatively unknown. We find that HCMV miRs UL112-1, US5-1, and US5-2 target multiple components of the host secreto...

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Hlavní autoři: Hook, Lauren M, Grey, Finn, Grabski, Robert, Tirabassi, Rebecca, Doyle, Tracy, Hancock, Meaghan, Landais, Igor, Jeng, Sophia, McWeeney, Shannon, Britt, William, Nelson, Jay A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029511/
https://ncbi.nlm.nih.gov/pubmed/24629342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.02.004
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