Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

AIMS/HYPOTHESES: Insulin-stimulated glucose transport in muscle is impaired in type 2 diabetes, presumably reflecting reduced activation of atypical protein kinase C (aPKC) and protein kinase B (PKB/Akt). As previously shown, reductions in aPKC activation are seen at sub-maximal and maximal insulin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Temofonte, N., Sajan, M. P., Nimal, S., Pastoor, T., Fumero, C., Casaubon, L., Powe, J. L., Standaert, M. L., Farese, R. V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029423/
https://ncbi.nlm.nih.gov/pubmed/18972094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-008-1180-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados