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The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling
The proinflammatory cytokine interleukin-17 (IL-17) is the signature cytokine of the T helper 17 (T(H)17) subset of CD4(+) T cells, and antibodies targeting IL-17 or the IL-17 receptor (IL-17R) show clinical efficacy in several autoimmune diseases. Although important for protective immunity against...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028484/ https://ncbi.nlm.nih.gov/pubmed/23737552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003699 |
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