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Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP
Mutation in presenilin 1 (PS1) is one of the leading causes of familial Alzheimer’s disease (fAD). PS1 mutation exacerbates the autophagic and lysosomal pathology in AD patients, leading to accumulation of partially degraded material in bloated lysosomes and autophagosomes – a pathology that bears s...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028113/ https://ncbi.nlm.nih.gov/pubmed/24418614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.01.001 |
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