Long-Term Episomal Transgene Expression from Mitotically Stable Integration-Deficient Lentiviral Vectors

Nonintegrating gene delivery vectors have an improved safety profile compared with integrating vectors, but transgene retention is problematic as nonreplicating episomes are progressively and rapidly diluted out through cell division. We have developed an integration-deficient lentiviral vector (IDL...

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Detalhes bibliográficos
Main Authors: Kymäläinen, Hanna, Appelt, J. Uwe, Giordano, Frank A., Davies, Angela F., Ogilvie, Caroline M., Ahmed, Sherif G., Laufs, Stephanie, Schmidt, Manfred, Bode, Juergen, Yáñez-Muñoz, Rafael J., Dickson, George
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027990/
https://ncbi.nlm.nih.gov/pubmed/24483952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.172
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