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Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but only one is expressed from a telomeric expres...

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Detalhes bibliográficos
Main Authors: Batram, Christopher, Jones, Nicola G, Janzen, Christian J, Markert, Sebastian M, Engstler, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027811/
https://ncbi.nlm.nih.gov/pubmed/24844706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02324
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