Development of Novel Benzomorpholine Class of Diacylglycerol Acyltransferase I Inhibitors

[Image: see text] Diacylglycerol acyltransferase 1 (DGAT1) presents itself as a potential therapeutic target for obesity and diabetes for its important role in triglyceride biosynthesis. Herein we report the rational design of a novel class of DGAT1 inhibitors featuring a benzomorpholine core (23n)....

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Detalhes bibliográficos
Main Authors: Zhou, Gang, Zorn, Nicolas, Ting, Pauline, Aslanian, Robert, Lin, Mingxiang, Cook, John, Lachowicz, Jean, Lin, Albert, Smith, Michelle, Hwa, Joyce, van Heek, Margaret, Walker, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027756/
https://ncbi.nlm.nih.gov/pubmed/24900877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400527n
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