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Himbacine-Derived Thrombin Receptor Antagonists: C(7)-Spirocyclic Analogues of Vorapaxar
[Image: see text] We have synthesized several C(7)-spirocyclic analogues of vorapaxar and evaluated their in vitro activities against PAR-1 receptor. Some of these analogues showed activities and rat plasma levels comparable to vorapaxar. Compound 5c from this series showed excellent PAR-1 activity...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027741/ https://ncbi.nlm.nih.gov/pubmed/24900880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500008w |
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