載入...
Himbacine-Derived Thrombin Receptor Antagonists: C(7)-Aminomethyl and C(9a)-Hydroxy Analogues of Vorapaxar
[Image: see text] We have synthesized several C(7)-aminomethyl analogues of vorapaxar that are potent PAR-1 antagonists. Many of these analogues showed excellent in vitro binding affinity and pharmacokinetics profile in rats. Compound 6a from this series showed excellent PAR-1 activity (K(i) = 5 nM)...
Na minha lista:
| Main Authors: | , , , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2013
|
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027727/ https://ncbi.nlm.nih.gov/pubmed/24900795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400452v |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|