Wordt geladen...
Himbacine-Derived Thrombin Receptor Antagonists: C(7)-Aminomethyl and C(9a)-Hydroxy Analogues of Vorapaxar
[Image: see text] We have synthesized several C(7)-aminomethyl analogues of vorapaxar that are potent PAR-1 antagonists. Many of these analogues showed excellent in vitro binding affinity and pharmacokinetics profile in rats. Compound 6a from this series showed excellent PAR-1 activity (K(i) = 5 nM)...
Bewaard in:
| Hoofdauteurs: | , , , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2013
|
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027727/ https://ncbi.nlm.nih.gov/pubmed/24900795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400452v |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|