Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors

[Image: see text] Matriptase belongs to trypsin-like serine proteases involved in matrix remodeling/degradation, growth regulation, survival, motility, and cell morphogenesis. Herein, we report a structure-based approach, which led to the discovery of sulfonamide and amide derivatives of pyridyl bis...

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Main Authors: Goswami, Rajeev, Mukherjee, Subhendu, Wohlfahrt, Gerd, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Chandra, Beeram Ravi, Sistla, Ramesh K., Satyam, Leena K., Samiulla, Dodheri S., Moilanen, Anu, Subramanya, Hosahalli S., Ramachandra, Murali
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2013
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027570/
https://ncbi.nlm.nih.gov/pubmed/24900621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400213v
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