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Rapid Determination of Ionization Constants (pK(a)) by UV Spectroscopy Using 96-Well Microtiter Plates

[Image: see text] We have developed a methodology that enables for the rapid measurement of ionization constants (pK(a)) of series of compounds by UV spectrophotometry. This protocol, which is straightforward to set up, takes advantage of the sensitivity of UV spectroscopy and the throughput enabled...

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Detalhes bibliográficos
Main Authors: Martínez, Carlos H. Ríos, Dardonville, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027549/
https://ncbi.nlm.nih.gov/pubmed/24900577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300326v
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