Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation

[Image: see text] A library of oxygenated natural steroids, including physalins, withanolides, and perulactones, coupled with the synthetic cage-shaped right-side structure of type B physalins, was constructed. SAR studies for inhibition of NF-κB activation showed the importance of both the B-ring a...

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Detalhes bibliográficos
Main Authors: Ozawa, Masaaki, Morita, Masaki, Hirai, Go, Tamura, Satoru, Kawai, Masao, Tsuchiya, Ayako, Oonuma, Kana, Maruoka, Keiji, Sodeoka, Mikiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027496/
https://ncbi.nlm.nih.gov/pubmed/24900739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400144e
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