Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X(7)-Evoked Glutamate Release

[Image: see text] We report the biological evaluation of a class of adamantane derivatives, which were achieved via modified telescoped machine-assisted flow procedure. Among the series of compounds tested in this work, 5 demonstrated outstanding analgesic properties. This compound showed that its a...

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Detalhes bibliográficos
Main Authors: Battilocchio, Claudio, Guetzoyan, Lucie, Cervetto, Chiara, Di Cesare Mannelli, Lorenzo, Frattaroli, Daniela, Baxendale, Ian R., Maura, Guido, Rossi, Antonietta, Sautebin, Lidia, Biava, Mariangela, Ghelardini, Carla, Marcoli, Manuela, Ley, Steven V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027228/
https://ncbi.nlm.nih.gov/pubmed/24900736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400079h
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