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Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus–Associated Mixed Cryoglobulinemia

OBJECTIVE: Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid factor (RF)–containing immune complexes and end-organ vasculitis. MC is a lymphoproliferative disorder in which B cells express RF-like Ig, yet...

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Hlavní autoři: Charles, Edgar D., Orloff, Michael I. M., Nishiuchi, Eiko, Marukian, Svetlana, Rice, Charles M., Dustin, Lynn B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026862/
https://ncbi.nlm.nih.gov/pubmed/23754128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38041
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