KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing

BACKGROUND: KRAS is one of commonly mutated genetic "drivers" in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so there is now a focus on targeting KRAS-mutated NSCLCs. A feasible mutation det...

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Detalhes bibliográficos
Main Authors: Lee, Boram, Lee, Boin, Han, Gangmin, Kwon, Mi Jung, Han, Joungho, Choi, Yoon-La
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Pathologists and The Korean Society for Cytopathology 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026800/
https://ncbi.nlm.nih.gov/pubmed/24868222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4132/KoreanJPathol.2014.48.2.100
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