Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization

Allosteric receptor–receptor interactions in GPCR heteromers appeared to introduce an intermolecular allosteric mechanism contributing to the diversity and bias in the protomers. Examples of dopamine D2R heteromerization are given to show how such allosteric mechanisms significantly change the recep...

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Bibliographic Details
Main Authors: Fuxe, Kjell, Tarakanov, Alexander, Romero Fernandez, Wilber, Ferraro, Luca, Tanganelli, Sergio, Filip, Malgorzata, Agnati, Luigi F., Garriga, Pere, Diaz-Cabiale, Zaida, Borroto-Escuela, Dasiel O.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026686/
https://ncbi.nlm.nih.gov/pubmed/24860548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00071
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