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Hypoxia-Mediated Mechanism of MUC5AC Production in Human Nasal Epithelia and Its Implication in Rhinosinusitis

BACKGROUND: Excessive mucus production is typical in various upper airway diseases. In sinusitis, the expression of MUC5AC, a major respiratory mucin gene, increases. However, the mechanisms leading to mucus hypersecretion in sinusitis have not been characterized. Hypoxia due to occlusion of the sin...

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Bibliografiske detaljer
Main Authors: Kim, Yoon-Ju, Cho, Hyung-Ju, Shin, Woo-Chul, Song, Hyun-Ah, Yoon, Joo-Heon, Kim, Chang-Hoon
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026485/
https://ncbi.nlm.nih.gov/pubmed/24840724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098136
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