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Septins set the stage for Orai1 to bind STIM1 at ER-PM junctions
The ER Ca(2+) sensor STIM1 recruits and activates the plasma membrane (PM) Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE). Reporting in Nature, Sharma et al. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding protein...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026033/ https://ncbi.nlm.nih.gov/pubmed/23906061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.07.012 |
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