Pediatric Brainstem Gangliogliomas Show BRAF(V600E) Mutation in a High Percentage of Cases

Brainstem gangliogliomas (GGs), often cannot be resected, have a much poorer prognosis than those located in more common supratentorial sites and may benefit from novel therapeutic approaches. Therapeutically targetable BRAF c.1799 T>A (p.V600E) (BRAF(V600E)) mutations are harbored in roughly 50%...

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Hlavní autoři: Donson, Andrew M., Kleinschmidt‐DeMasters, Bette K., Aisner, Dara L., Bemis, Lynne T., Birks, Diane K., Levy, Jean M. Mulcahy, Smith, Amy A., Handler, Michael H., Foreman, Nicholas K., Rush, Sarah Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025990/
https://ncbi.nlm.nih.gov/pubmed/24238153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12103
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