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Pediatric Brainstem Gangliogliomas Show BRAF(V600E) Mutation in a High Percentage of Cases

Brainstem gangliogliomas (GGs), often cannot be resected, have a much poorer prognosis than those located in more common supratentorial sites and may benefit from novel therapeutic approaches. Therapeutically targetable BRAF c.1799 T>A (p.V600E) (BRAF(V600E)) mutations are harbored in roughly 50%...

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Detalhes bibliográficos
Main Authors: Donson, Andrew M., Kleinschmidt‐DeMasters, Bette K., Aisner, Dara L., Bemis, Lynne T., Birks, Diane K., Levy, Jean M. Mulcahy, Smith, Amy A., Handler, Michael H., Foreman, Nicholas K., Rush, Sarah Z.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025990/
https://ncbi.nlm.nih.gov/pubmed/24238153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12103
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