Biotin Analogues with Antibacterial Activity Are Potent Inhibitors of Biotin Protein Ligase

[Image: see text] There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target for new antibiotics. We repo...

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Main Authors: Soares da Costa, Tatiana P., Tieu, William, Yap, Min Y., Zvarec, Ondrej, Bell, Jan M., Turnidge, John D., Wallace, John C., Booker, Grant W., Wilce, Matthew C. J., Abell, Andrew D., Polyak, Steven W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2012
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025796/
https://ncbi.nlm.nih.gov/pubmed/24900501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300106p
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