Biotin Analogues with Antibacterial Activity Are Potent Inhibitors of Biotin Protein Ligase

[Image: see text] There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target for new antibiotics. We repo...

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Autori principali: Soares da Costa, Tatiana P., Tieu, William, Yap, Min Y., Zvarec, Ondrej, Bell, Jan M., Turnidge, John D., Wallace, John C., Booker, Grant W., Wilce, Matthew C. J., Abell, Andrew D., Polyak, Steven W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025796/
https://ncbi.nlm.nih.gov/pubmed/24900501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300106p
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