Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A

[Image: see text] An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of ∼350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neurotoxin serotype A (BoNT A). Subsequent acquisition and testing of analogu...

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Detalhes bibliográficos
Main Authors: Cardellina, John H., Roxas-Duncan, Virginia I., Montgomery, Vicki, Eccard, Vanessa, Campbell, Yvette, Hu, Xin, Khavrutskii, Ilja, Tawa, Gregory J., Wallqvist, Anders, Gloer, James B., Phatak, Nisarga L., Höller, Ulrich, Soman, Ashish G., Joshi, Biren K., Hein, Sara M., Wicklow, Donald T., Smith, Leonard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025784/
https://ncbi.nlm.nih.gov/pubmed/24900483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200312s
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