Synthesis and Biological Evaluation of Cyclic Sulfamide Derivatives as 11β-Hydroxysteroid Dehydrogenase 1 Inhibitors

[Image: see text] A new series of cyclic sulfamide derivatives were synthesized and evaluated for their ability to inhibit 11β-HSD1. Among this series, 18e showed good in vitro activity toward human 11β-HSD1, selectivity against 11β-HSD2, microsomal stability, and pharmacokinetic and safety profiles...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kim, Se Hoan, Bok, Ju Han, Lee, Jae Hong, Kim, Il Hyang, Kwon, Sung Wook, Lee, Gui Bin, Kang, Seung Kyu, Park, Ji Seon, Jung, Won Hoon, Kim, Hee Yeon, Rhee, Sang Dal, Ahn, Sung Hoon, Bae, Myung Ae, Ha, Deok Chan, Kim, Ki Young, Ahn, Jin Hee
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025780/
https://ncbi.nlm.nih.gov/pubmed/24900439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200226x
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires