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Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis†
[Image: see text] Metronidazole (MTZ), the FDA-approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance, while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen piperidine dithiocarbamate hybrids of 2-(2-methyl-5-nitro-1H-imida...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American
Chemical Society
2011
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025769/ https://ncbi.nlm.nih.gov/pubmed/24900434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200161t |
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