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Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis†

[Image: see text] Metronidazole (MTZ), the FDA-approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance, while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen piperidine dithiocarbamate hybrids of 2-(2-methyl-5-nitro-1H-imida...

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Detalhes bibliográficos
Main Authors: Kumar, Lalit, Jain, Ashish, Lal, Nand, Sarswat, Amit, Jangir, Santosh, Kumar, Lokesh, Singh, Vishal, Shah, Priyanka, Jain, Swatantra K., Maikhuri, Jagdamba P., Siddiqi, Mohammad I., Gupta, Gopal, Sharma, Vishnu L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025769/
https://ncbi.nlm.nih.gov/pubmed/24900434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200161t
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